Humulene is a terpene that occurs naturally in the flowering hops plant.
This is one of the most prevalent 20 terpenes found in Cannabis. When extracted, Humulene appears in a pale yellowish-green clear liquid. It can actually make up for 40% of the essential oil extracted from the hops plant. We can actually thank humulene for the “hoppy” aroma of beer. It is the reaction of humulene to the extraction process that creates this scent. This is another sesquiterpene derived from farnesyl diphosphate (FPP). When the FPP is catalyzed by sesquiterpene synthesis enzymes humulene is formed.
There are diverse ways to synthesize this terpene in the lab. Some of these methods are the Corey synthesis, McMurray synthesis, Takahashi synthesis, and de Groot synthesis. It occurs naturally in cannabis strains like White Widow, Girl Scout Cookies, Pink Kush, Headband, Sour Diesel and Skywalker OG. Many describe the aroma of humulene as a woody scent.
α-Humulene is currently found in cannabis strains and:
- Pine Trees
- Marsh Elders
- Chinese laurel tree
- Sunflower fields
This terpene, like β-caryophellene, is sometimes referred to as a cannabinoid. It also works best as an anti-inflammatory when paired in a strain with β-caryophellene. This anti-inflammatory action is one of the reasons that certain strains help ease the chronic pain of arthritis, fibromyalgia, and other naggingly painful illnesses. For this reason, these terpenes are commonly found in pain relief balms and salves.
A study from Planta Medica was done on this terpene. The results showed that it helped the body produce chemicals called Reactive Oxygen Species that help destroy cancer cells through aptosis. Other studies show that humulene can suppress hunger unlike many other strains that give us ultra munchies.
This terpene is being studied as an:
- Appetite Suppressant
Molecular Weight: 204.35628000
Boiling Point: 106 to 107 °C (223 to 225 °F; 379 to 380 K) at 5 mmHg
Density: 886 kg/m³